Mechanotransduction Cellular Biology Diagrams Living cells and tissues experience physical forces and chemical stimuli in a human body. The process of converting mechanical forces into biochemical activities and gene expression is mechanochemical transduction or mechanotransduction. Significant
Since the main annotation for YAP/TAZ transcription targets lies within the proliferation category, the activity of Hippo effectors in the nucleus has been historically associated with cell growth and tumor spreading (Zanconato et al., 2015), while our group and others lately proved that the mechanotransduction role of YAP is to be ascribed to Mechanotransduction is the ability of a cell to sense mechanical cues from its microenvironment and convert them into biochemical signals to elicit adaptive transcriptional and other cellular responses. Here, we describe recent advances in the field of mechanical regulation of transcription, highlight mechanical regulation of the epigenome as a key novel aspect of mechanotransduction, and
Mechanisms of mechanotransduction and physiological roles of PIEZO ... Biology Diagrams
The mechanically activated cation channels PIEZO1 and PIEZO2 are crucial for mechanotransduction processes in mammals. This Review discusses the structural design and gating dynamics of PIEZO
Mechanotransduction and cell-cycle progression. Although the focus on cell-cycle regulation has historically been on biochemical cues, it is becoming increasingly appreciated that mechanical cues play a key role. Cell-cycle progression begins at division completion. Cells will typically either enter the G0 or quiescent phase, in which they do
Cellular Mechanotransduction: From Tension to Function Biology Diagrams
In nonhematopoietic mammalian cell types, cell cycle progression requires adhesion and spreading on a solid substratum. Loss of this requirement for anchorage correlates closely with tumorigenicity in vivo and is related to the ability of cancer cells to invade and metastasize into other tissues (Huang and Ingber, 1999). RhoA signalling in fibrosis. A positive feed-forward cycle is illustrated. Transforming growth factor-beta (TGFฮฒ) is released in response to tissue wounding. Severing the LINC complex, or complete removal of the nucleus, alter a cell's mechanotransduction. Much of the change may be due to reduced RhoA activity. The reason why RhoA activity
